Symbol
Name
ID

Tbx1
T-box 1
MGI:98493

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Microcephaly

Drooling

Cerebral calcification

Hemiparesis

Delayed speech and language development

Emotional lability

Paranoia

Schizophrenia

Bipolar affective disorder

Aggressive behavior

Attention deficit hyperactivity disorder

Intellectual disability

Global developmental delay

Specific learning disability

Seizure

Disease(s) Associated with TBX1

DiGeorge syndrome

hypoparathyroidism

velocardiofacial syndrome

Mouse Phenotypes

abnormal neuron differentiation

abnormal forebrain morphology

abnormal vestibulocochlear ganglion morphology

abnormal cochlear ganglion morphology

cochlear ganglion degeneration

abnormal geniculate ganglion morphology

abnormal glossopharyngeal ganglion morphology

abnormal trigeminal ganglion morphology

abnormal vagus ganglion morphology

vestibular ganglion degeneration

abnormal cranial nerve morphology

abnormal accessory nerve morphology

abnormal facial nerve morphology

abnormal glossopharyngeal nerve morphology

fusion of glossopharyngeal and vagus nerve

glossopharyngeal nerve hypoplasia

abnormal trigeminal nerve morphology

abnormal mandibular nerve branching

abnormal vagus nerve morphology

abnormal vestibulocochlear nerve morphology

decreased prepulse inhibition

Availability

Mouse Genotype

Tbx1^nmf219/Tbx1^nmf219

Tbx1^tm1Bem/Tbx1^tm1Bem

Tbx1^tm1Bld/Tbx1^tm1Bld

Tbx1^tm1Pa/Tbx1^tm1Pa

Tbx1^tm1Bem/Tbx1⁺

Tbx1^tm1Bld/Tbx1⁺

Tbx1^tm2.1Bem/Tbx1^tm2.2Bem
Foxg1^tm1(cre)Skm/Foxg1⁺ (conditional)

Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺
Foxg1^tm1(cre)Skm/Foxg1⁺ (conditional)

Mesp1^tm2(cre)Ysa/Mesp1⁺
Tbx1^tm1Bld/Tbx1^tm3Bld (conditional)

Tbx1^tm2.1Bem/Tbx1^tm2.2Bem
Tg(Pax2-cre)1Akg/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23